Hemisecalonic acids

In 2008, the long-anticipated but never-before-detected monomeric components of the secalonic acids (blennolides and hemisecalonic acids 895 to 900, Fig. 13.9) were isolated from an endophytic Blennoria sp., in addition to secalonic acid B (1037) (vide infra) (Fig. 13.9) and several other biosynthetically related isolates, named blennolides A-G (895-901) (633). The structure of blennolide A (895), the monomeric unit of secalonic acid B (1037), was confirmed using single-crystal X-ray analysis blennolide B (896) is the monomeric unit of secalonic acid D (1035). The configurations of all these compounds were ascertained using CD spectra to determine the absolute stereochemistiy of the 10a position as (R), and... 

Ohnemuller, UK, Nising, CF, Encinas A, Erase S (2007) A Versatile Access to Enantiomerically Pure 5-Substituted 4-Hydroxy-2-cyclohexenones. An Advanced Hemisecalonic Acid A Model. Synthesis 2175... 

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See also in sourсe #XX -- [ , ]

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