HEMA-styrene triblock copolymers

HEMA-Styrene Triblock Copolymers and Polyether-Segmented Polyamide... 

Drug Release from PHEMA-l-PIB Networks. Amphiphilic networks due to their distinct microphase separated hydrophobic-hydrophilic domain structure posses potential for biomedical applications. Similar microphase separated materials such as poly(HEMA- -styrene-6-HEMA), poly(HEMA-6-dimethylsiloxane- -HEMA), and poly(HEMA-6-butadiene- -HEMA) triblock copolymers have demonstrated better antithromogenic properties to any of the respective homopolymers (5-S). Amphiphilic networks are speculated to demonstrate better biocompatibility than either PIB or PHEMA because of their hydrophilic-hydrophobic microdomain structure. These unique structures may also be useful as swellable drug delivery matrices for both hydrophilic and lipophilic drugs due to their amphiphilic nature. Preliminary experiments with theophylline as a model for a water soluble drug were conducted to determine the release characteristics of the system. Experiments with lipophilic drugs are the subject of ongoing research. 

Monodisperse terfluorene segments were used by our group for the syntheses of diblock copolymers 19 and triblock copolymers 20 utilizing a CRP technique. " The rods were synthesized via classical organic synthesis and were then used as macroinitiators for the ATRP of styrene, tert-butyl acrylate (tBA), and 2-hydroxyethyl methacrylate (HEMA). 

In 1976, Okano, Shinohara et al. [77] synthesized, by radical polymerization processes, a triblock (A-B-A) copolymer, consisting of HEMA (A) and styrene (B) ... 

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