Heck reaction silane-terminated intramolecular

As an application of this methodology to the syntheses of natural products, Sannicolo et al. have reported the preparation of benzazepine and tetra-hydroisoquinoline derivatives by silane-terminated intramolecular Heck reactions. These workers argued that one main disadvantage of the Heck reaction... 

The general procedure for a silane-terminated intramolecular enantioselective Heck reaction is exemplified by Scheme 3-60 [61a,b, 259]. A mixture of [Pd2(dba)3 - CHCI3] (0.025 mmol,... 

Scheme 3-5 Silane-terminated intramolecular Heck reaction [61].

Tietze, L.E. and Schimpf, R. (1994) Regio- and enantioselective silane-terminated intramolecular Heck reactions. Angew. Chem., Int. Ed. Engl., 33,1089-91. 

Tietze, L.R and Modi, A. (2000) Regioselective silane-terminated intramolecular Heck reaction with alkenyl trillates and alkenyl iodides. Eur. J. Org. Chem., 1959-64. 

Scheme 7.4 Syntheses of benzazepines and tetrahydroisoquinolines by intramolecular silane-terminated Heck reactions with (T )-BITIANP and ( + )-TMBTP ligands.

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