Heck reaction biologically active compounds applying

Syntheses of Heterocycles, Natural Products, and Other Biologically Active Compounds Applying Heck Reactions... 

Table 8.8 Syntheses of important natural products and biologically active compounds applying the Heck reaction (Figure 8.7 and Figure 8.8) [422].

As most biologically active compounds - natural and noimatural products - contain heterocyclic substractures, intramolecular C-C-bond-forming processes including Heck reactions have been applied to accompHsh heterocydization [564-566]. 

Figure 8.7 Some biologically active compounds prepared by applying Heck reactions with asymmetric induction. The dashed lines indicate bonds formed by palladium.catalyzed...

Due to the high levels of selectivity, functional group tolerance and the mild reaction conditions typically applied, the Heck reaction has been adapted in a number of total syntheses, some of them depicted in Scheme 1.23. In addition, industrial processes relying on the aspects displayed by the Heck reaction, have been established and resulted in large scale productions of pharmaceutical and biological active compounds (Scheme 1.24) [77, 89, 90]. Because of the high... 

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