Heck-Mizoroki/Suzuki-Miyaura domino reaction

A palladium(II)-catalysed Heck-Mizoroki/Suzuki-Miyaura domino reaction of arylboronic acids with vinyl ethers (34), catalysed by (CF3C02)2Pd and using p-benzoquinone (p-BQ) as reoxidant, has been developed. The key importance of the... 

Recently, Yahiaoui et al. developed a chelation-controlled palladium-catalyzed Heck-Mizoroki/Suzuki-Miyaura domino reaction involving metal-coordinating dimethylaminoethyl vinyl ethers and various electron-deficient and electron-rich arylboronic acids by the use of p-Bq as the oxidant [22] (Scheme 6.13). The two-carbon tethered dimethylamino moiety, which could combine with p-Bq for the stabilization of the o-alkylpalladium(II) intermediate 56 and formation of the dia-rylated products 57, is assumed to be crucial for avoiding the formation of Heck products 58. 

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