Heat-shock protein system receptors

Details of the activation and transport into the nucleus remain unknown. It is assumed that the complex between receptor and hormone and the loosely associated heat shock proteins reaches the nucleus via a protein transport system. After dissociation of the heat shock proteins, the hormone-receptor complex is capable of specific binding on the HRE and of transactivation. 

Carver, L.A., V. Jackiw, and C.A. Bradfield (1994). The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system. J. Biol. Chem. 269, 30109-30112. 

Imamura T, Haruta T, Takata Y, Usui I, Iwata M, Ishihara H, Ishiki M, Ishibashi O, Ueno E, Sasaoka T, Kobayashi M (1998) Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. J Biol Chem 273 11183-11188 Jensen TJ, Loo MA, Pind S, Williams DB, Goldberg AL, Riordan JR (1995) Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83 129-135 Johnson AE, van Waes MA (1999) The translocon a dynamic gateway at the ER membrane. Annu Rev Cell Dev Biol 15 799-842... 

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