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Notes National primary ambient air quality standards define levels of air quality which the EPA Administrator judges are necessary, with an adequate margin of safety, to protect the public health. National secondary ambient air quality standards define levels of air quality, which the Administrator judges necessary to protect the public welfare from any known or anticipated adverse effects of a pollutant. 

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This work was supported by the intramural program of the National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892. 

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This article is dedicated to the memory of Vincent G. Dethier. I thank Drs. Thomas A. Christensen and Leslie P. Tolbert for helpful comments on the manuscript and my many present and former coworkers and collaborators, who contributed to the work from my laboratory reviewed in this paper. Our research in this area has been supported by grants from the National Institutes of Health, National Science Foundation, and the Department of Agriculture and is currently supported by National Institutes of Health Grants AI-23253, NS-28495, and DC-00348. 

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Acknowledgments We thank David Huhman for assistance with mass spectrometry analysis. This work was supported by the National Institutes of Health National Center for Complementary and Alternative Medicine (award 1 POl AT004511) and the Samuel Roberts Noble Foundation. 

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This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering. The authors would like to thank Terry M. Phillips for his guidance and for his valuable assistance, especially with the sections on electrochemical and radiochemical detectors. 

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