Hateruma island

III trials in Europe) [70]. The biomedical potential of the ascidian metabolites has resulted in these primitive chordates. As part of our ongoing chemical and biological studies on Okinawan marine organisms, we investigated an ascidian Lissoclinum sp. collected off the coast of Hateruma Island. A lipophilic extract of the ascidian showed that it could inhibit the division of fertilized sea urchin eggs. 

The light blue sponge was collected by hand from the coast of Hateruma Island. The acetone extract was initially partitioned between EtOAc and water. The cytotoxic EtOAc extract was fractionated by silica-gel column chromatography and ODS HPLC to furnish hateramadysin A (58, 0.0010% of wet weight), haterumadysin B (59, 0.00047%), haterumadysin C (60, 0.00022%), haterumadysin D (61, 0.00042%), (-)-spirodysin (62,0.0030%), and (-)-dehydroherbadysinolide (63, 0.00042%). 

An unusual iodinated 5 -deoxyxylofuranosyl nucleoside was isolated from an unidentified species of the genus Diplosoma collected at Hateruma Island, Okinawa. This compound inhibits the division of fertilized sea urchin eggs (Margiastuti et al, 2008). 

Haterumadysins A-D are sesquiterpenes with a new bicyclic skeleton. They were isolated from a species of Japanese origin (Hateruma Island, Okinawa), Dysidea chlorea, and inhibit the division of sea urchin eggs (Ueda et al, 2006). Haterumadysins were isolated with spirodysin, previously identified from Dysidea herbacea and Dysidea sp. (Kazlauskas, Murphy, and Wells, 1978b,... 

Haterumalides are simpler macrolides than the previous ones, but of a new kind. They were isolated in the same year, and by the same team, from a sponge of the genus Ircinia and an ascidian of the genus Lissoclinum, both collected around Hateruma Island in the Okinawa archipelago (Takada et al, 1999 Ueda and Hu, 1999). Hater-umalide B was isolated from the tunicate and haterumalides NA-NE from the sponge. All these macrolides have the same lactone ring with 14 members and contain a vinyl chloride. 

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