Harmonic oscillators peptides

Several reviews on various aspects of oxazole chemistry have been published. Cicchi and co-workers and Gilchrist reviewed synthesis and reactions of oxazoles. Walsh and co-workers " reviewed the biosynthesis of thizazole and oxazole peptides, including microcin B17 1196. Kawase and co-workers reviewed the synthesis of 5-(trifluoromethyl)oxazoles via Dakin-West chemistry. Suga and Ibata reviewed much of their work on [3 - - 2] cycloadditions of 5-alkoxyoxazoles. In addition, Mrozek and co-workers applied the harmonic oscillator model of aromaticity (HOMA) index to live-membered ring heterocycles, including oxazoles. 

Figure 13 Energy level scheme for a system of two coupled oscillators. The isolated peptide states (left side) are coupled by some weak interaction, which mixes them to generate the excitonic states (right side). Anharmonicity, which is crucial for understanding the 2D pump probe spectra, is introduced into this model by lowering the energies of the double excited monomeric site states i2) and j2) by A from their harmonic energies 2eu- This anharmonicity mixes into all coupled states, giving rise to diagonal anharmonicity (Ae ) and off-diagonal anharmonicity (mixed-mode anharmonicity, Ae i) in the basis of the normal modes discussed in the text.

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