Harmonic-mean termination

The unbound PCP concentration was calculated by multiplying the total unchanged PCP concentration In serum by the unbound fraction in serum at each time point. The harmonic means for the terminal elimination half-life for unchanged total PCP and unbound PCP were virtually the same (3.5 and 3.3 hours, respectively). The arrows indicate the time of Fab administration. 

To describe the termination rate coefficient s dependence on chain length, the geometric and harmonic means are employed (equations 8 and 9). ... 

Olaj and Zifferer [229] have performed Monte Carlo simulations in which they placed 300 polymer chains in a lattice, considering excluded volume effects. From the obtained configurations they evaluated the shielding factor which describes how severely the presence of a polymer coil retards the termination of its own radical compared to small (unshielded) radicals. For chains of unequal size Olaj and Zifferer showed that the geometric mean model provided a reasonable mathematical description of their results, although the harmonic mean model. 

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