Haloperoxidase, biological halogenations

Van Pee, K.-H., Dong, C., Flecks, S. etal. (2006) Biological halogenation has moved far beyond haloperoxidases. Advances in Applied Microbiology, 59, 127-157. [Pg.32]

Alkene halogenation reactions occur in nature just as they do in the laboratory but are limited primarily to marine organisms, which live in a halide-rich environment. The biological halogenation reactions are carried out by enzymes called haloperoxidases, which use H2O2 to oxidize Br or Cl ions to a biological... [Pg.266]

There are a number of biological examples of halohydrin formation, particularly in marine organisms. As with halogenation (Section 8.2), halohydrin formation is carried out by haloperoxidases, which function by oxidizing Br or Cl ions to the corresponding HOBr or HOCl bonded to a metal atom in the enzyme. Electrophilic addition to the double bond of a substrate molecule then yields a bromonium or chloronium ion intermediate, and reaction with water gives the halohydrin. For example ... [Pg.257]

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