Indometacin Haloperidol

NSAIDs ANTIPSYCHOTICS 1. Reports of T sedation when indometacin was added to haloperidol 2. Risk of agranulocytosis when azaproprazone is given with clozapine 1. Unknown 2. Unknown 1. Avoid co-administration 2. Avoid co-administration... 

In 19 patients with malignant disease taking high doses of morphine (daily doses of 500 mg or more orally or 250 mg or more parenterally), an analysis was made of the relationship between myoclonus and the use of supplemental drugs. In the 12 patients with myoclonus, 8 patients were taking antidepressants (amitriptyline, doxepin) or antipsychotics (chlorpro-mazine, haloperidol) compared with none of 6 patients without myoclonus. In addition, there was a higher use of NSAIDs (indometacin, naproxen, piroxicam, aspirin) and an antiemetic (thiethylperazine). The reasons are not understood, and the findings of this paper have been questioned. ... 

Profound drowsiness and confusion have been described in patients given haloperidol with indometacin. 

An 80-year-old man taking haloperidol, procyclidine, clonazepam, aspirin, digoxin and lithium (serum levels between 0.5 and 0.7 mmol/L) was additionally given indometacin 100 mg daily for arthritis, which was replaced, after 13 days, by ketorolac 30 mg daily. The next day his serum-lithium level was 0.9 mmol/L and 6 days later 1.1 mmol/L. Subsequently the patient developed severe nausea and vomiting, and both drugs were stopped. ... 

Class 2 (High PermeabiUty, Low Solrrbility) Azathioprine, Azithromycin, Alprazolam, Warfarin, Haloperidol, Glipizide, Griseofulvinum, Danazol, Dapsone, Diclofenac, Indometacin, Itraconzol, Carbamazepine, Carvedilol, Ketoconazole, Lansoprazol, Mebendazole, Mefloqrrine, Nalidixic acid. Nevirapine, Piroxicam, Praziquantel, Ritonavir, Rifampicinirm, Spironolactone, Tamoxifen, Terfenadine, Trimethoprim, Ibnprofen, lopanoic add, Lovastatin, Naproxen, Oxaprozin, Flubiprofen, Cisapride. ... 

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