Haloperidol hyperprolactinemia with

Hyperprolactinemia with osteopenia has been attributed to haloperidol (432). 

The prevalence of hyperprolactinemia in patients with chronic schizophrenia taking long-term haloperidol has been studied in 60 patients in Korea (28 women illness mean duration, 15.5 years) (472). There was hyperprolactinemia, defined as a serum prolactin concentration over 20 ng/ml in men and 24 ng/ml in women, in 40 the prevalence of hyperprolactinemia in women (93%) was significantly higher than in men (47%). There was also a... 

The effects of haloperidol and quetiapine on serum prolactin concentrations have been compared in 35 patients with schizophrenia during a drug-free period for at least 2 weeks in a randomized study (475). There was no significant difference in prolactin concentration between the groups at the start of the study control prolactin concentrations were significantly lower with quetiapine than with haloperidol. Two patients taking haloperidol had galactorrhea related to hyperprolactinemia. 

Jung DU, Seo YS, Park JH, Jeong CY, Conley RR, Kelly DL, Shim JC. The prevalence of hyperprolactinemia after long-term haloperidol use in patients with chronic schizophrenia. J Clin Psychopharmacol 2005 25 613-5. 

Arita J, Kimura F (1986) Characterization of in vitro dopamine synthesis in the median eminence of rats with haloperidol-induced hyperprolactinemia and bromocriptine-induced hypoprolactinemia. Endocrinology 779 1666-1672. 

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