Halogenopyrazines thiolysis

Note There appear to be no recent examples of the direct thiolysis of extranuclear halogenopyrazines All such transformations have been done indirectly via an isothiouronium intermediate (cf. Section 4.2.4). 

Most tautomeric pyrazinethiones have been made by primary synthesis (see Chapters 1 and 2), thiolysis of halogenopyrazines (see Section 4.2.4), or thiation of tautomeric pyrazinones (see Section 5.1.2.1) a few nontautomeric pyrazinethiones by primary synthesis (see Chapters 1 and 2) or thiation of nontautomeric pyrazinones (see Section 5.4.2) and nearly all extranuclear pyrazinethiols by thiolysis of extranuclear halogenopyrazines (see Section 4.4). Other routes to such pyrazinethiones and pyrazinethiols are illustrated in the following examples ... 

---