Halogenated molecules, pharmaceutical

This is a reagent used in analytical chemistry. Its chemical structure is very similar to dinitrochloroben-zene, which is the prototype of the halogenated molecules as far as irritant and contact allergenic properties are concerned. Brasch (1991) reported on a pharmacist working in a pharmaceutical laboratory who developed an acute dermatitis on her hands, forearms, face, and neck. 

Very recently, Wu et al. developed an eflhcient Fe/Cu relay-catalyzed domino protocol for the synthesis of pharmaceutically significant 2-phenylquinazoIin-4-amines 67 from commercially available ortlzo-halogenated benzonitriles, aldehydes, and sodium azide (Scheme 7.47) [115]. This elegant domino reaction involved consecutive iron-mediated [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, oxidation, and copper-catalyzed denitrogenation sequences. The structure constructed by this protocol is the privileged core in drugs and bioactive molecules. 

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