Halofantrine Magnesium carbonate

Aideloje SO, Onyeji CO, Ugwu NC. Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate. Eur J Pharm... [Pg.425]

Magnesium carbonate halves the maximum plasma levels of halofantrine, which may be clinically relevant. Aluminium hydroxide and magnesium trisilicate seem less likely to interact. [Pg.229]

Magnesium carbonate 1 g reduced the maximum plasma levels of halofantrine 500 mg by almost 50% in a single-dose study in healthy subjeets. The AUC was also redueed by 28%, but this was not statistically significant. The aetive metabolite of halofantrine, which is equally potent, was similarly affeeted. ... [Pg.229]

Magnesium carbonate might decrease the absorption of halofantrine. In vitro study showed that the halofantrine absorptive eapaeity of various antacids was highest for magnesium carbonate, intermediate for aluminium hydroxide, and least for magnesium trisilicate. ... [Pg.229]

The pharmacokinetic interaction between halofantrine and magnesium carbonate appears to be established. Its clinical importance does not seem... [Pg.229]

Big Chemical Encyclopedia