Halocarbonyl Compounds and Derivatives 2-Aminothiazoles

The 2-aminothiazoles are extracted with ether after alkalinization of the reaction mixture. The yields are almost theoretical with a-haloketones and lower with a-haloaldehydes. 

A new method of synthesizing 2-aminothiazoles from thiourea and ketones has been developed by Dodson (225, 261, 280). It was improved by King and Lavacek (328) and later taken up by several other workers (328, 779, 798) (Method B). 

214 General Synthetic Methods for Thiazole and Thiazolium Salts 

This simplified method gives 2-aminothiazole in good yield (50 to 70%) (311, 330), Other reactants can replace iodine, for example, chlorine, bromine, sulfuryl chloride, chlorosulfonic acid, or sulfur monochloride also give good results. 

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