Haldane simplification

This equation now expresses initial net forward rate for the conversion of substrate into product in the presence ofsignificant concentrations ofboth [S] and [P]. Any relationship that relates any equilibrium constant to kinetic rate constants is known as a Haldane relationship. Equation (8.61) is a typical Haldane relationship. Therefore, the operation using Equation (8.61) to simplify Equation (8.60) to give (8.62) is known as a Haldane simplification -owing to the use of a Haldane relationship to effect the simplification. Clearly, if there is no... 

The King-Altman approach described here can be summarised as a process in which an original rate equation (such as Equation (8.53)) is customarily developed, converted into a coefficient form (such as Equation (8.54)) and from there simplified to steady state kinetic forms (for example Equations (8.62) and (8.63)) by algebraic manipulation and Haldane simplification. This King-Altman approach is an approach that can be generalised for the derivation of most steady state kinetic equations based upon most complex kinetic schemes. Clearly these derivations can be substantial, but we shall not bother to reproduce these here except to cover a few important examples of particular relevance to the biocatalyst examples described in Section 8.1. 

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See also in sourсe #XX -- [ ]

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