Hairpin exchanger applications

Used by permission Bui. Application and Design Estimating of Double Pipe and Hairpin Exchangers. Brown Eintube Co., A Koch Engineering Co., Houston, Texas. 

Thermodynamic parameters of ground-state conformational equilibria T , AH , AS ) are obtained from analyses of cs vs. temperature profiles of non-exchangeable protons (and of C profiles as well, see [83L3]). In this way, the thermodynamic behavior of individual residues in an oligomer strand can be monitored this is in contrast to optical methods (ultraviolet of circular dichroism), which trace only the overall melting behavior. However, precautions must be taken in order to account for the effect of intermolecular association upon the observed cs values [82H1]. The method is particularly applicable to sh/rc equilibria and also to the melting equilibrium of relatively short dh structures, hairpins, etc. J vs. temperature profiles appear less well suited for this purpose. 

Use double-pipe exchangers. These are indeed true counter-current flow exchangers (also called hairpins). I often use these. They are reliable and robust, but if the required capacity exceeds several hundred square feet, they are too small for many applications. 

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