Groups H-bonding

The [Co(phen)3]3+ complex is photoactive and a powerful oxidant in its excited state. The ion has no H-bonding groups and hence is considerably more hydrophobic1279 than hexaamine relatives. These properties have proven particularly useful. Aryl and alkyl substituted [Co(phen)3]3+ complexes have received a great deal of attention due to their ability to intercalate within the helical structure of DNA through a combination of electrostatic and hydrophobic forces. The chirality of the tris-chelate complex is crucial in determining the degree of association between the complex and... 

Roberts MS, Pugh WJ, Hadgraft J (1996) Epidermal permeability-penetrant structure relationships 2. The effect of H-bonding groups in penetrants on their diffusion through the stratum comeum. Int J Pharm 132 23-32. 

Classification of the hydrogen group orbitals. The H-H bonding group orbital, hv transforms as a +, and the H-H anti-bonding group orbital, h2, transforms as cu+. The detailed conclusions are dealt with in Section 3.2.1. 

The first part of the right side of Eq. (1) gives the portion of the H-bonded OH groups with the concentration (1-Of) the second part gives the portion of the non H-bonded OH groups with the concentration 0F. The partial molar volume of H-bonded groups and the coefficient of thermal expansion is taken as ice like datas. Both properties of the orientation defects are adjusted. Spectroscopy cannot give informations on these constants. Therefore, the proof of the orientation defects assumption by the density is not very accurate. 

Rehydration of the surface is found to be reversible only if the pretreatement temperature is kept below about 400°C. Above that temperature a restructuring of the surface apparently occurs. The removal of the H-bonded groups removes the adsorption site for water thus giving rise to a surface which does not adsorb water very readily at low pressure (Fig. 2). 

Fig. 4.2. The relationship between the estimated diffusion parameter (DU) in the stratum corneum and the number of H-bonding groups attached to the permeant. (Data adapted...

Laplacian is roughly proportional to the bond density, as one would normally expect. Thus, the C-C and the C-H bonds fall in the first region of the plot while the C-O and the O-H bonds group fall in the second... 

H BONDING GROUP SUBSTANCE REFS. SUBSTANCE REFS. 

Predicted permeabilities based on H-bonding groups and PSA would suggest that SB-415286 would have the least and at the other end of the spectrum SB-216763 would have extremely good permeability (low PSA, high lipophilicity and few solvating atoms). The exquisitely potent Lilly-41 has a lot of H-bond acceptors, one of which is a urea such that the AlogP of the com-... 

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