Gustatory sweating

Botulinum toxin is used clinically in the treatment of blepharospasm, writer s cramp, spasticities of various origins, and rigidity due to extrapyramidal disorders. It is also used to treat gustatory sweating and cosmetically to decrease facial wrinkles. Botulinum toxin A Botox, Oculinum) injected intramuscularly produces functional denervation that lasts about 3 months. Clinical benefit is seen within 1 to 3 days. Adverse effects range from diplopia and irritation with blepharospasm to muscle weakness with dystonias. 

In 22 patients with Frey syndrome (localized facial gustatory sweating and flushing) treated with topical glycopyrrolate 0.5-2% in a solution, cream or roll-on lotion, 1012 applications were recorded (SEDA-8,160). There were seven adverse events blurred vision (one), minor eye infections (two), itchy or dry eyes (one), and dry mouth (three). In the control group blurred vision and dry mouth were also recorded as adverse events. 

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