Guinea pig metabolism

Comparative studies with acetaminophen indicate that metabolism in the hamster resembles more closely that in man than in mouse. d-Limonene (32) is metabolized in rat, rabbit and hamster preferentially to C-l carboxylic acid derivatives, whereas dog and man largely form the 8,9-diol, and the guinea pig metabolizes 32 by these two pathways to the same extent . Compound 41 is substantially oxidized by rat and guinea pig, but not man, to biphenylacetic acid this possibly explains the ineffectiveness of 41 in rheumatoid arthritis . Sedative-hypnotic 42 is N-hydroxvIated in the cat, a more... 

The author points out that the rat is much more resistant to digoxin than the guinea-pig, but guinea-pigs metabolize digoxin to a greater extent than the rat... 

---