Guidance on process analytical technologies

Multivariate analysis (MVA) is the statistical analysis of many variables at once. Many problems in the pharmaceutical industry are multivariate in nature. The importance of MVA has been recognized by the US FDA in the recent guidance on process analytical technology [3]. MVA has been made much easier with the development of inexpensive, fast computers, and powerful analytical software. Chemometrics is the statistical analysis of chemical data. Spectral data from modern instruments is fundamentally multivariate in character. Furthermore, the powerful statistical methods of chemometrics are essential for the analysis and application of spectral data including NIR and Raman. In this section, we will briefly review the subject of chemometrics and MVA. 

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