Guanosine monophosphate reductase

Figure 3. Compartmentalization of the purine salvage pathway of Leishmania. Abbreviations are as follows AAH, adenine aminohydrolase XPRT, xanthine phosphoribosyltransferase HGPRT, hypoxanthine-guaninephosphoribosyltransferase ADSS, adenylosuccinate synthetase ASL, adenylosuccinate lyase IMPDH, inosine monophosphate dehydrogenase GMPS, gua-nosine monophosphate synthase GDA, guanine deaminase AMPDA, adenosine monophosphate deaminase GMPR, guanosine monophosphate reductase APRT, adenine phosphoribosyltransferase AK, adenosine kinase. Enzymes that have been localized are shown in black and those that are predicted to be in the denoted locations are depicted in gray.

Fig. 173. Interconversion of inosine, adenosine and guanosine monophosphates 1 Inosine monophosphate dehydrogenase 2 guanosine monophosphate synthase 3 guanosine monophosphate reductase 4 adenylosuccinate synthetase 5 adenylosuccinate lyase 6 adenosine (phosphate) deaminase...

Spector, T. and Jones, T. E. (1982) Guanosine 5 -monophosphate reductase from Leishmania donovani. A possible chemotherapeutic target. Biochem. Pharmacol. 31 3891-3897. 

GMP reductase (EC 1.6.6.8) a flavin enzyme which catalyses the conversion of guanosine S -monophosphate to inosinic acid in a sin e step. It is part of the system for converting guanine to adenine compounds. 

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