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Guanine amine protection

The preparation of chloromercurio derivatives of the purines presents some difficulties. A method for circumventing this problem has been found with the use of mercury(II) cyanide or mercury(II) acetate as a condensation catalyst.The use of mercury(ll) cyanide also simplified the synthesis of guanine nucleosides. Treatment of 6-chloropurin-2-amine with excess hexamethyidisilazane, followed by treatment with 2-deoxy-3,5-di-C>-(4-toluoyl)-a-D-ribofura-nosyl chloride and mercury(ll) cyanide in benzene and finally deprotection of the resulting protected a- and )S-anomeric nucleosides 7 provides an elTicicnt synthesis of a- and )S-2 -de-... [Pg.433]

See other pages where Guanine amine protection is mentioned: [Pg.182]    [Pg.637]    [Pg.558]    [Pg.195]    [Pg.187]    [Pg.706]    [Pg.790]    [Pg.880]    [Pg.218]    [Pg.551]    [Pg.50]    [Pg.158]    [Pg.13]    [Pg.1464]    [Pg.60]    [Pg.195]    [Pg.166]   
See also in sourсe #XX -- [ Pg.6 , Pg.642 ]

See also in sourсe #XX -- [ Pg.642 ]

See also in sourсe #XX -- [ Pg.6 , Pg.642 ]

See also in sourсe #XX -- [ Pg.642 ]



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Guanin

Guanine

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