Guanidino-phosphines

Similarly, Pd(OAc)2 modified with the guanidino phosphines 92 (Table 5 n=l,2) catalysed the Heck reaction between 4-iodobenzoic acid and 4-carboxy-... 

More recently, complexes obtained by association of Pd(OAc)2 and the cationic guanidino phosphine 10 were also shown to be very active catalysts for this coupling reaction [115-118]. They were mainly used in the synthesis of modified proteins by coupling amino acids containing alkyne or iodoaryl groups with... 

Strongly basic cationic phosphine ligands 75, 76 containing guanidino functions were prepared either in the reaction of 3-... 

Strongly basic cationic phosphine ligands 75, 76 containing guanidino functions were prepared either in the reaction of 3-aminopropyldiphenylphosphine with lH-pyrazole-l-carboxamide under basic conditions in DMF [75] or by the addition of dimethylcyanamide to the amino groups of tertiary (3-aminophenyl)phosphines in acidic medium [70], These phosphines (as acetate or chloride salts) are highly soluble in water in some cases the solubility reaches that of TPPMS. Another noteworthy feature of these compounds that they are considerably less sensitive to air oxidation then the anionic (e.g. sulfonated) phosphines. 

Dibowski H. Schmidtchen. F.P. (1995) Synthesis and investigation of phosphine-ligands containing cationic guanidino functions in aqueous Heck reactions. Tetrahedron, 51, 2325-30. 

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