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5-guanidino-4-nitroimidazole

NHE, which is a strong enough oxidant to abstract an electron from dG (i ° = 1.29 V vs. NHE ) to yield G +. Following deprotonation of G + to yield the neutral radical G(—H), reaction with N02 produces 8-nitro-dG and the 5-guanidino-4-nitroimidazole derivative (NI) following attachment of N02 at C-5 of G(—H) (Scheme 4). ... [Pg.184]

New oligonucleotides containing 5-guanidino-4-nitroimidazole were obtained from deoxyguanosine with peroxynitrite [538],... [Pg.50]

Guanidino-4-nitroimidazole formation in peroxynitrite-treated DNA was characterized by electrospray ionization mass spectrometry with selected reaction monitoring [409],... [Pg.340]

Gu F, Stillwell WG, Wishnok JS, Shallop AJ, Jones RA, Tannenbaum SR (2002) Per-oxynitrite-induced reaetions of synthetic oligo 2 -deoxynucleotides and DNA containing guanine formation and stability of a 5-guanidino-4-nitroimidazole lesion. Biochemistry 41 7508-7518... [Pg.89]

Neeley WL, Henderson PT, Delaney JC, Essigmann JM (2004) In vivo bypass elEcien-cies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem 279 43568-43573... [Pg.89]

See other pages where 5-guanidino-4-nitroimidazole is mentioned: [Pg.182]    [Pg.152]    [Pg.153]    [Pg.153]    [Pg.154]    [Pg.419]    [Pg.206]    [Pg.340]    [Pg.371]    [Pg.470]    [Pg.23]    [Pg.403]    [Pg.405]    [Pg.409]    [Pg.410]    [Pg.411]    [Pg.411]    [Pg.424]    [Pg.426]    [Pg.431]    [Pg.64]   
See also in sourсe #XX -- [ Pg.41 , Pg.95 ]



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