Guaiane, Pseudoguaiane, Patchoulane, Seychellane

The new guaiane alcohol (728) has been identified in the soft coral Nephthea chabrolii.328 The vast majority of new guaiane sesquiterpenoids are guaian-6a,12-olides and these are listed in the Table.61 152 224 228 230 231 233 241 242 251 329-339 In 

Commun., 1981, 46, 941. 

A full report on the short stereocontrolled synthesis of racemic patchouli alcohol has been presented,362 the key steps of which are the Grignard addition of the magnesium derivative of the bromide (796) to the dienone (797) followed by an intramolecular Diels-Alder reaction. The preparation of the two enantiomers of 

An earlier synthesis of seychellene (801) has been reported in full and improvements in some key steps have been accomplished.365 (Vol. 9, p. 155, Vol. 11, p. 84). 

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