Grunwald diagrams

Figure 5-24. The u.v and x,y coordinate systems of Grunwald s analysis of the RIP diagram. The u.v coordinates are in parentheses and the jr,y coordinates are in brackets.

The Bronsted relation has proved to be a useful equation for correlating rate and equilibrium results for proton transfer reactions. However, following the analysis by Leffler and Grunwald [73] in 1963 considerable effort has been made to go further than this and understand why the relation should hold, and also to attach some significance to the values of a and 3 in terms of the structure of the transition state for proton transfer. An alternative approach from that to be discussed here interprets the Bronsted relation from molecular potential energy diagrams [74]. 

SCHEME 9. Grunwald disparity diagram for malate synthase. 

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