Group reactions with

Alkimide group Reaction with HI to produce Rl AgN03 Agl... 

Isocyanates are Hquids or soHds which are highly reactive and undergo addition reactions across the C=N double bond of the NCO group. Reactions with alcohols, carboxyUc acids, and amines have been widely exploited ia developiag a variety of commercial products. Cycloaddition reactions involving both the C=N and the C=0 double bond of the NCO group have been extensively studied and used for product development (1 9). 

The carboxyl groups of amino acids undergo all the simple reactions common to this functional group. Reaction with ammonia and primary amines yields unsubstituted and substituted amides, respectively (Figure 4.9a,b). Esters... 

Secondary steric effects of nitro groups are more easily detected by comparing the reactivities with those of aza derivatives. For example, in structure 20 the rate depression on passing from methyl to -butyl is only 2.5-fold and can be attributed to an inductive effect, whereas in structure 21 a similar change involves the factor 16, which can be attributed in part to steric inhibition of resonance (S.I.R.) of thep-N02 group (reaction with piperidine). 

Electrophilicity of the S02 and SO groups (reaction with bases/nucleophiles). 

Figure 1.110 The reaction of SANH with an amine-containing molecule results in an amide bond derivative that terminates in a protected hydrazine group. Reaction with an aldehyde-containing molecule results in release of the acetone-protecting group and formation of a stable hydrazone bond.

U.S. producers and capacities, 2 800t Methylene fluoride, 13 720-721 Methylene groups, reaction with ozone, 17 781... 

Product Difference NaOH-NajCO, neutralization Acid-resistant —OCHj groups Reaction with ... 

Various allylhalostannanes can transfer allyl groups to carbonyl compounds. In this case, the reagent acts both as a Lewis acid and as the source of the nucleophilic allyl group. Reactions with halostannanes are believed to proceed through cyclic transition states. 

The phase-transfer catalyst, Bu N Cl, reacts with CN to form a quaternary cyanide salt that is slightly soluble in the organic phase because of the bulky, nonpolar, butyl groups. Reaction with CN" to form the nitrile is rapid because it is not solvated or ion-paired in the organic phase it is a free, strong nucleophile. The... 

It is to be expected that furo[2,3-ft]pyrazines would show an appreciably lower reactivity in electrophilic substitution than benzo[fe]furans. Bromination of 2-phenylfuro[2,3-6]pyrazine requires high temperatures and long reaction times the substitution takes place in position 3. By contrast, nitration occurs mainly in the phenyl group. Reaction with peracids easily provides the N-7 monoxide. This is to be expected since quantum mechanical calculations (HMO, PPP, CNDO) all predict a higher charge density at N-7 compared with N-5. 

Cl, N02) undergoes cod substitutions with isocyanides and phosphines.190 However, when R is the strongly electron withdrawing N02 group, reaction with PEt3 leads to nucleophilic attack on the coordinated cod ligand affording (63) instead of cod substitution. 

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