Group interchange method of Drefahl and Reinhard

A values depend on the interchanged groups (Gx, Gy or G, G() and on their neighbor groups. The derivation of A values will be demonstrated for the replacement of a methyl group, -CH3, by a bromomethyl group, -CHaBr. Table 13.5.1 lists log Kow and A of corresponding compound pairs related by this particular 

Assume that methyl group is attached to methylene group Delete  

TABLE 13.5.1 Derivation of A (replacement of -CH3 by -CH2Br) Using Experimental log Kow 

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