Group I and II Metal Ketone Enolates

The tables that follow provide additional examples not cited in the foregoing discussion and further amplify the conclusions drawn above. Table 7 summarizes the influence of the ketone substituent Ri on 

Kinetic Aldol Condensations of Acyclic Lithium Ketone Enolates with Benzaldehyde (eq. [17]) (2,26) 

Enolate Ligand Ri Base Enolate Ratio Z-.E Erythro-Threo Product Ratio  

lithium hexamethyldisilylamide LTMP, lithium 2,2,6,6-tetramethyl-piperidide. 

A large number of studies have addressed the condensation of cyclic ketones with both aliphatic and aromatic aldehydes under conditions that reflect both thermodynamic (cf. Table 2) and kinetic control of stereochemistry. The data for cyclohexanone enolates are summarized in Table 8. Except for the boryl enolates cited (6), the outcome of the kinetic aldol process for these enolates 

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