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Grinding polymorph control

A.V. Trask, W.D.S. Motherwell, W. Jones, Solvent-drop grinding green polymorph control of cocrystallization, Chem. Commun. (2004) 890-891. [Pg.387]

Solvent-drop grinding is a novel, efiScient and green procedure for polymorphic control [15,16]. It involves grinding a known polymorph of a compound with a very small amount of solvent added in order to effect a polymorphic transformation. Variation of the solvent may lead to different polymorphic outcomes. For example, polymorphic Form I of anthranilic acid (Figure 1, 2), ground in the presence of heptane, transforms to Form II, which in turn converts to Form III whai ground in tiie presence of chloroform [15]. [Pg.600]

Polymorph control by solvent-drop grinding during co-crystallization of caffeine with glutaric acid. [Pg.7]

See other pages where Grinding polymorph control is mentioned: [Pg.41]    [Pg.59]    [Pg.68]    [Pg.105]    [Pg.467]    [Pg.366]    [Pg.117]    [Pg.18]    [Pg.85]    [Pg.679]    [Pg.203]    [Pg.8]    [Pg.10]    [Pg.12]    [Pg.254]    [Pg.616]   
See also in sourсe #XX -- [ Pg.59 ]



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