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Grignard reagents with isocyanides

Isocyanides that do not contain an a hydrogen react with alkyllithium compounds, as well as with Grignard reagents, to give lithium (or magnesium) aldimines. These metalated aldimines are versatile nucleophiles and react with various substrates as follows ... [Pg.1252]

Methoxyphenyl isocyanide, 41, 103 Methyl crotonate, reaction with -butyl Grignard reagent and cuprous chloride, 41, 63... [Pg.58]

Grignard reagents fail to react with dihydro-1,3-oxazines unsubstituted at C-2, but n-butyllithium in diethyl ether yields 2-butyltetrahydro-l,3-oxazines. However, the reaction is solvent-dependent and in THF the ring is opened to give isocyanides (69TL5151). [Pg.1007]

Yields were low with primary Grignard reagents except for benzylmagnesium bromide tertiary and aromatic Grignard reagents failed to react with the isocyanide to any appreciable extent. [Pg.643]

Substituted glycines (171) have been prepared by Michael addition of Grignard reagents to 2-isocyanoacrylate esters (170), and the a-metallated isocyanide species (172) is found to react with simple Schiff s bases to give 2-imidazolines which on... [Pg.106]

See other pages where Grignard reagents with isocyanides is mentioned: [Pg.323]    [Pg.228]    [Pg.323]    [Pg.614]    [Pg.228]    [Pg.228]    [Pg.164]    [Pg.733]    [Pg.739]    [Pg.164]    [Pg.164]    [Pg.733]    [Pg.196]    [Pg.44]    [Pg.1271]    [Pg.2960]    [Pg.421]    [Pg.51]    [Pg.52]    [Pg.377]    [Pg.733]    [Pg.164]    [Pg.421]    [Pg.733]    [Pg.51]    [Pg.52]    [Pg.60]    [Pg.642]    [Pg.2959]    [Pg.324]    [Pg.1271]    [Pg.4725]    [Pg.222]    [Pg.112]   
See also in sourсe #XX -- [ Pg.981 ]



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Isocyanide reagents

Isocyanides reactions with Grignard reagents

With Grignard Reagents

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