Grignard reagents organomagnesium

Grignard reagents (organomagnesium compounds) are extremely useful in many organic reactions. These materials are relatively easy to prepare, but they re very sensitive to trace amounts of moisture and air and decompose if either is present. 

Grignard reagent (organomagnesium halide) (Section 18.5) An oiganometallic species with a carbon—magnesium bond RMgX. 

Grignard reagents Organomagnesium halides RMgX having a C-Mg bond, halohydrins Halo alcohols. For example, ethylene bromohydrin is BrCH2CH20H. helicenes Ortho-fused polycyclic aromatic compounds that have a helical structure. 

Grignard reagents - Organomagnesium halides, RMgX, having a carbon-magnesium bond (or their equilibrium mixtures in solution with R Mg + MgX ). [5]... 

The best known among unstabilized carbanionic derivatives are the Grignard reagents (organomagnesium compounds) and organolithiums ... 

Grignard reagents, organomagnesium halides, are prepared by the reaction of metallic magnesium with a wide range of organic halides (reaction 9.3). Dry ether type solvents are essential. 

Grignard reagent (Section 14 4) An organomagnesium com pound of the type RMgX formed by the reaction of magne Slum with an alkyl or aryl halide... 

Oddo reported that the organomagnesium derivatives of p3Trole, indole, skatole, and carbazole could be prepared in a single operation by mixing the parent heterocyclic compound with an alkyl halide and magnesium in anhydrous ether.The product formed was reported to be the same as that obtained by the more conventional procedure. However, this approach to the synthesis of the indole Grignard reagents does not seem to have been exploited in subsequent work. 

An interesting example of the organomagnesium synthesis is to be found in the use of 1,4-addition of the Grignard reagent to 4-alkyl-ideneisoxazol-5-ones (91) to prepare saturated isoxazol-5-ones (92). 

The reaction of Grignard reagents with carbonyl compounds has no direct biological counterpart, because organomagnesium compounds are too... 

Grignard reagent (Section 10.7) An organomagnesium halide, RMgX. 

Grignard received the Nobel Prize in 1912 and organomagnesium halides are now called Grignard reagents. 

---