Grignard cross coupling reaction

Figure 3.49. Chiral ligands that exhibit high enantioselectivity in the nickel-catalyzed Grignard cross-coupling reaction of vinyl bromide (or chloride) with 1-phenylethylmagne-sium chloride.

Aryl O-Carbamate and S-Thiocarbamate-Grignard Cross-Coupling Reactions... 

Banno, T., Hayakawa, Y., Umeno, M. Some applications of the Grignard cross-coupling reaction in the industrial field. J. Organomet. Chem. 2002, 653, 288-291. 

The compound 12 is an extremely useful ligand for nickel-catalyzed Grignard cross-coupling reactions and allows the enantioselective synthesis of biaryls in over 90%ee36,37 (Sections D. 1.1.3. and B.2.). 

Table 14.11 The Grignard cross-coupling reactions with O-carbamates, triflates, and S-carbamates.

The synthesis of an isotopically labeled molecule through the use of a unique Grignard cross-coupling reaction in the presence of dichloro[l,3-bis(diphenylphosphino)propane]nickel(ll). 

The final con und, 33, was prepared by a Grignard cross coupling reaction between diketene (39) and -butylmagnesium bromide in the presence of anhydrous cobalt iodide (30, 34). It is noteworthy that the Grignard reagent attacks the methylene carbon instead of the carbonyl carbon in the presence of cobalt iodide. 

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