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Gribble reduction of diaryl ketones

Reduction of diaryl ketones and diarylmethanols to diarylmethanes using sodium borohydride in trifluoroacetic acid. Also applicable to diheteroaryl ketones and alcohols. [Pg.163]

The Gribble reduction of diaryl ketones refers to the sodium borohydride-trifluoroacetic acid (NaBHVTFA) reduction of diaryl ketones (1) to diarylmethanes (2).1 The reaction is very general and is applicable to the reduction of diarylmethanols (3) and triarylmethanols (4) to the respective diarylmethanes (2) and triarylmethanes (5).2... [Pg.93]

Gribble reduction of diaryl ketones Additive reduction... [Pg.340]

G. W. Gribble, W. J. Kelly, and S. E. Emery. Reactions of sodium borohydride in acidic media VII. Reduction of diaryl ketones in trifluoroacetic acid. Synthesis, 1978, 763. [Pg.58]

Following the discovery of the ability of NaBHVRCC H to effect the reduction and N-alkylation of indoles,12 Gribble and co-workers found that diaryl ketones are smoothly reduced to diarylmethanes using NaBFL/TFA.1 A year earlier it was found that diarylmethanols and triarylmethanols are similarly reduced to the respective hydrocarbons.2... [Pg.93]

See other pages where Gribble reduction of diaryl ketones is mentioned: [Pg.281]    [Pg.85]    [Pg.93]    [Pg.765]    [Pg.281]    [Pg.810]    [Pg.163]    [Pg.678]    [Pg.281]    [Pg.85]    [Pg.93]    [Pg.765]    [Pg.281]    [Pg.810]    [Pg.163]    [Pg.678]   
See also in sourсe #XX -- [ Pg.163 ]

See also in sourсe #XX -- [ Pg.145 ]



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