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Grb2 protein binding inhibitors

Figure 1.14 NMR-structure of the Grb2-SH2 domain in complex with inhibitor 39. A central antiparallel P-sheet in the protein is flanked by two a-helices, with peptide binding mediated by the sheet, intervening loops, and one of the helices. The specific recognition of phospho-tyrosine involves cation-tr interactions between... Figure 1.14 NMR-structure of the Grb2-SH2 domain in complex with inhibitor 39. A central antiparallel P-sheet in the protein is flanked by two a-helices, with peptide binding mediated by the sheet, intervening loops, and one of the helices. The specific recognition of phospho-tyrosine involves cation-tr interactions between...
See other pages where Grb2 protein binding inhibitors is mentioned: [Pg.51]    [Pg.199]    [Pg.486]    [Pg.170]    [Pg.21]    [Pg.99]    [Pg.205]    [Pg.308]    [Pg.198]    [Pg.204]    [Pg.255]    [Pg.92]    [Pg.308]    [Pg.187]    [Pg.65]    [Pg.316]   
See also in sourсe #XX -- [ Pg.203 ]



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