Granulation variables process impact

Table 3 Significant Variables and Their Impact on the Fluid-Bed Granulation Process...

In the milling, blending, granulating and or drying processes, the operating principles of the equipment employed should be defined, and the variables determined. The impact and mechanism of measurement on in-process variables should be defined. Time, temperature, work input of equipment, blend/ granulation volume, and granulating rate should be determined. 

Granulation particle size did not impact the release rate. In addition, tableting at various compression forces had no significant impact on the release rate of the tablets. This knowledge that variability in tablet manufacture resulted in a uniform sustained release dosage form provided an advantage for further process optimization and scale-up, as shown in Figure 23. 

The variables in the fluid bed granulation process and its impact on the final granulation were summarized by Davies and Gloor Jr. [92] they state that the... 

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