Solvent granulation

If no fluidized bed is available water should be avoided as granulation solvent. 

Moisture content of dried granulation Loss on drying (LOD) can be used to determine whether or not the granulation solvent has been removed to a sufficient level during the drying operation (usually less than 2% moisture). 

Amount of binder solution/granulating solvent How much binder or solvent solution is required to granulate the material Too much binder or solvent solution will overwet the materials and prolong the drying time. The amount of binder solution is related to the binder concentration. 

Binder solution/granulating solvent addition rate Define the rate or rate range at which the binder solution or granulating solvent can be added to the materials. Can the granulating solution be dumped into the mixer or does it have to be metered in at a specific rate ... 

Granulating solvent Water Water Water Water... 

Drug solubility in the granulation solvent can effect its distribution in different granule size fractions, thus the granules can come Into the drying process as wet granules that are... 

Immobile liquids—addition of specialty binders that sorb the granulating solvent, soften, deform, and adhere to particles, then harden during drying. 

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