Granulation disintegrants

Fig. 8 Hanging drop slide with well used to study granule disintegration...

Possibility of combining drying with other operations (e.g., granulation, disintegration, heating, cooling, chemical reactions)... 

As an alternative dosage form to ease swallowing, not only are oral liquids an option but also chewable tablets, granules, disintegrating tablets, oromucosal or orodisper-sible tablets. 

Prepare a starch suspension by mixing 1 gm. of potato starch with 10 ml. of water. Starch is insoluble in cold water. Examine a drop of the suspension microscopically. Note characteristic laminated granules, which stain darkly with Od per cent, iodine. Pour the starch suspension into about 90 ml. of boiling water. The granules disintegrate, forming a colloidal solution of starch. 

Ghdants are needed to faciUtate the flow of granulation from the hopper. Lubricants ensure the release of the compressed mass from the punch surfaces and the release/ejection of the tablet from the die. Combinations of siUcas, com starch, talc (qv), magnesium stearate, and high molecular weight poly(ethylene glycols) are used. Most lubricants are hydrophobic and may slow down disintegration and dmg dissolution. 

Ammonium Nitrate Plant 7. Prill lower reduce microprill formation and reduce carryover of fines through entrainment. 8. Materials handling where feasible use covers and hoods on conveyors and transition points. Good cleanup practices must be in place to minimize contamination of stormwater mnoff from the plant property. 9. Granulators reduce dust emissions from the disintegration of granules. 

Enzymes. Where tablets are not naturally very cohesive and have thus been manufactured by a wet granulation process involving one of the binders listed in Table 8, addition of small quantities of appropriate enzyme may be sufficient to produce rapid disintegration. It has also been proposed that disintegration action might result from expansion of the entrapped air due to generation of heat of wetting when the tablet is placed in a fluid. This concept has received little attention. 

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