Gradient polymer elution chromatography critical conditions

The molecular-statistical theory of polymer solutions in confined media was also applied to the conventional chromatographic theory of gradient elution [ 163]. This approach leads to the prediction of the special mode of interactive polymer chromatography gradient elution at critical point of adsorption. It was demonstrated theoretically and experimentally that under appropriate conditions elution of each compositionally homogeneous fraction of copolymer occurs at the critical mobile phase composition. This critical mobile phase composition depends only on the local structure of the copolymer chain and is independent of its molecular weight. As a consequence, gradient elution produces the chemical com-... 

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