Gossypol molecule

Mohammad RM, et al. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) ((-)-gossypol) against diffuse large cell lymphoma. Mol. Cancer Ther. 2005 4 13-21. 

Figure 2 Small-molecule antagonists of prosurvival Bcl-2 proteins (a) ABT-737 (19) (b) GeminX (21) (c) Yale (20) (d) Gossypol (16) and (e) the University of Michigan (22).

Figure 2 Centers of asymmetry may consist of one of several forms, (a) A carbon atom most commonly forms the chiral center, as is seen for halofantrine. (b) Sulfur atoms may form the center of asymmetry in some molecules, such as omeprazole, (c) In ifosfamide, a phosphorous atom is the center of asymmetry, (d) In some case, such as gossypol, a plane of asymmetry is formed not at a single atom, but rather between two atoms (the bond linking the two aromatic groups).

Fig. 2 Clathrate of gossypol with chloroform. Guest molecules are disordered in four positions. (View this art in color at www.dekker.com.)...

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