Good Manufacturing Practice, small

These chapters contain specific information about the principles of assays defined in the text and contain what may well be the most comprehensive guide to the science of measurement in the scientific literature. Both the NF and the Nutritional Supplements have their own general chapters. Guidelines to Good Manufacturing practices are supplied, with guidance to small-scale pharmaceutical operations such as those encountered in a typical dispensing pharmacy. 

Some food chemicals have uses other than as food chemicals—in fact, the food-grade material may be only a small part of production for industrial or other uses. In such situations, the principles of good manufacturing practices must apply, and particular attention must be paid to the suitability of the raw materials used the prevention of crosscontamination and the segregation of food chemicals from nonfood chemicals, including material in process, final product, and product in storage. The necessary controls to ensure the above must be developed and implemented. 

Figure 19.23 Drug development-related multitasking. Although big pharma typically has specialized teams of pharmaceutical chemists dedicated to various of these activities, it is not uncommon in small pharma for drug discovery medicinal chemists to become actively involved with several (or all) of these tasks relative to each final lead compound that may progress into development. Note that the final toxicity and clinical batches must be prepared and formulated according to Good Manufacturing Practices (GMP) accompanied by Good Laboratory Practices (GLP) anaiyticai support.

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