Gonystylus keithii

Gonystylus keithii (Thymelaeaceae) Gonystylus keithii (Thymelaeaceae) Gonystylus keithii (Thymelaeaceae) Gonystylus keithii (Thymelaeaceae)... 

A second example of this same NCI procedure resulted in the rapid identification of cucurbitacin D from a novel source (55). The pattern of cytotoxic activity observed from a crude extract of Gonystylus keithii against renal, brain, and melanoma subpanels correlated strongly with the pattern observed earlier for purified cucurbitacins B, E, and I (Scheme 5). This bioprofile indication led to the expeditious fractionation and identification of cucurbitacin D as the anticancer active component in the extract. 

Fuller, R. W., Cardellina, J. H., Cragg, G. M., and Boyd, M. R. (1994) Cucurb-itacins differential cytotoxicity, dereplication and first isolation from Gonystylus keithii. J. Nat. Prod. 57,1442—1445. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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