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Gonioma Malagasy

The pyrrolonaphthyridines 208 and 209 can be prepared from rearrangement of the pentacycle 207 upon treatment with trifluoroacetic acid (TFA) (Scheme 52). These products are of interest as they have the same structural skeleton as the indole alkaloid (—)-goniomitine, isolated from the root bark of Gonioma Malagasy <1995JOC3282>. Compound 208 has since been used in the synthesis of further derivatives which show cytotoxic activity against leukemia cells <2001BML79>. [Pg.896]

Goniomitine (135), an alkaloid of a new structural type from the root bark of Gonioma malagasy E. May, is apparently the result of a much more far-reaching transformation of a vincadifformine precursor (146). Its structure was deduced on the basis of an analysis of its NMR spectra, including a comparison of its C chemical shift data with those of tryptophol and guettardine (136). It is included in this group on the basis of its presumed derivation from vincadifformine (77) by a series of plausible, unexceptional... [Pg.38]

Beniddir, Martin, Dau, Rasoanaivo, Gueritte, and Litaudon extracted some alkaloids from Gonioma malagasy The extraction contained the following steps ... [Pg.446]

Beniddir MA, Martin M-T, Dau M-ETH, Rasoanaivo P, Gueritte F, Litaudon M. Bisindole alkaloid artifacts from Gonioma malagasy. Tetrahedron Lett 2013 54 (17) 2115-9. [Pg.446]

See other pages where Gonioma Malagasy is mentioned: [Pg.208]    [Pg.238]    [Pg.13]    [Pg.446]    [Pg.300]    [Pg.301]    [Pg.208]    [Pg.238]    [Pg.13]    [Pg.446]    [Pg.300]    [Pg.301]   
See also in sourсe #XX -- [ Pg.446 ]

See also in sourсe #XX -- [ Pg.300 ]



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