Gold Standard Approaches

Compliance. There is a common approach, taken by companies looking at ELN systems, to view them as risky this is mostly in comparison to what is seen as the gold standard of reliability and low risk, the paper notebook. In fact, there is an alternative approach to thinking about the implementation of an IP and regulatory records management system (which is just what a paper or electronic notebook is) that does take into consideration the risks associated with paper notebooks. 

Potentiometric methods for solubility measurement have been reported in the literature [467-471]. A novel approach, called dissolution template titration (DTT), has been introduced [472-474], One publication called it the gold standard [509]. 

Everything considered, sonoelastography is a very challenging approach for characterization of mechanical waves. To become the gold standard in non-invasive elastography, US methods should provide good anatomic localization of the viscoelastic properties as well as the 3D assessment of the wave pattern. But such improvements would possibly make sonoelasticity methods slower and less convenient. 

Figure 1.12 Determining the properties of drug molecules. Drug molecules may have their properties ascertained by either experimental or theoretical methods. Although experimental methods, especially X-ray crystallography, are the gold standard methods, calculational approaches tend to be faster and do provide high qnality information. Nonempirical techniques, such as ab initio quantum mechanics calcnlations, provide accnrate geometries and electron distribution properties for drng molecnles.

---