Gold catalysis Mannich reaction

Scheme 7.39 Domino redox-pinacol-Mannich reaction catalysed by chiral phosphoric acid catalysis and gold catalysis.

Later, an enantioselective one-pot tandem Mannich-hydroamination reaction was reported by Liu and co-workers on the basis of a sequential organo- and gold catalysis.The proeess involved propargylated malonitrile and oxindole imine derivatives as substrates and employed a chiral cinchona alkaloid, such as a quinidine phenol derivative, to induce the enantioselective Mannich reaction and a gold catalyst, such as XPhosAuNTfa... 

Scheme 7.64 Tandem nitro-Mannich-hydroamination-isomerisation reaction catalysed by chiral urea catalysis and gold catalysis.

Scheme 7.65 Tandem Mannich-hydroamination reaction catalysed 1 chiral cinchona alkaloid catalysis and gold catalysis.

---