Going Beyond Process Analyzers Towards Solutions

3 Going Beyond Process Analyzers Towards Solutions 

Another view of how PAT provides a holistic nnderstanding of a mannfactnring process is presented by Wold el al. ° who describe four levels of PAT describing the chemometrics analysis of data and the complexity and objective of measurements. 

Off-line chemical analysis in labs to a large extent snbstitnted by at-line analysis - e.g., spectroscopy, fast chromatography, imaging, and sensor arrays. Mnltivariate calibration nsed to convert PAT data to traditional space (e.g., concentrations, disintegration rate). 

At-line PAT data nsed directly without conversion back to the original variables space - e.g., MVI (Mnltivariate Identification), MSPC (multivariate statistical process control). 

On-line PAT data measnred during batch evolntion of each prodnction step - e.g., on-line MSPC, BSPC (batch statistical process control). 

---