Glyoxalyl chloride

A cold, stirred solution of 1-phenyl-piperazine in tetrahydrofuran was treated all at once with [3-(2-methyl-5,6-dimethoxy)indolyl]glyoxalyl chloride. There was an immediate voluminous precipitate of a white crystalline solid which was removed by filtration. The filtrate was taken to dryness and the residual light brown gum was stirred and shaken with water, ethyl acetate and acetic acid. The mixture was warmed on a steam bath and the resulting solid was collected after cooling in an ice bath thus affording l-[(3-(2-methyl-5,6-dimethoxy)indolyl)glyoxalyl]-4-phenylpiperazine as a near white solid, melting point 163°-174°C. 

Glyoxalines s. Imidazoles Glyoxalyl chloride tosyl-hydrazone as reactant 26,201 Glyoxylic acids... 

Reactions of aroyl chlorides with neat hexamethyldisilane at 110°C are effectively catalyzed by [(7/3-C3H5)PdCl]2with triethylphosphite to give benzoyltrimethylsilane in satisfactory yields (14—71%). Aryltrimethylsilanes are also formed in a few cases. This reaction is apphcable to a variety of ortho-, meta-, and /lara-substituted aroyl chlorides. Under these conditions, phenyl-glyoxalyl chloride produces benzoyltrimethylsilane as the sole product in 52% yield through a facile decarbonylation process. ... 

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